Human aldehyde reductase promoter allows simultaneous expression of two genes in opposite directions

Human aldehyde reductase promoter allows simultaneous expression of two genes in opposite directions.

Are Usability and Security Two Opposite Directions in Computer Systems?

Instinct tells us that computer security and computer usability are inversely proportional to each other. In other words, the tougher and stricter the security is, the less usability there is, and vice versa. However, there have been plenty of cases where both computer security and computer usability went hand in hand with each other and actually improved together. In the last few years securit...

Promoter Methylation of Four Tumor Suppressor Genes in Human Papillary Thyroid Carcinoma

Background & Objective: Papillary thyroid cancer (PTC) is considered to be the most common type of thyroid malignancies. Epigenetic alteration, in which the chromatin conformation and gene expression change without changing the sequence of DNA, can occur in some tumor suppressor genes and oncogenes. Methylation is the most common type of epigenetic alterations that can be an ex...

Opposite momenta lead to opposite directions

When a particle decays into two fragments, the wavefunctions of the latter are spherical shells with expanding radii. In spite of this spherical symmetry, the two particles can be detected only in opposite directions. When particles at rest decay into two fragments, the latter have opposite momenta, p1 + p2 = 0. (1) Yet, the statistical distribution of each fragment is isotropic. The same holds...

Identification of two initiator elements in the bidirectional promoter of the human dihydrofolate reductase and mismatch repair protein 1 genes.

The human dihydrofolate reductase (DHFR) gene and mismatch repair protein 1 (MRP1) genes are organized in a head-to-head configuration separated by an 90 base pair sequence. We have previously shown that as small as a 114 bp promoter sequences is sufficient for accurate and efficient initiation of divergent transcription. In this study, the mechanism of accurate transcription initiation in vivo...